This resource provides information for manufacturers on practices that can improve data quality to aid in DSCSA implementation. The document, originally published in 2022, was updated by HDA’s Exceptions Handling Work Group, comprising manufacturers and wholesale distributors that convened to identify common pathways to handle data and product exceptions that are expected to occur when trading partners begin exchanging serialized transaction data. The best practices reflected here helped participating manufacturers accurately capture and aggregate product serialization data, and are described for the benefit of other manufacturers seeking to provide accurate product serialization data to downstream trading partners to meet the 2025 DSCSA requirements.