Developed by HDA’s eCommerce Task Force, this electronic data interchange (EDI) transaction set presents the format and explains the application of the Accredited Standards Committee (ASC) X12 standards as they pertain to the Product Transfer Account Adjustment transaction set for use within the context of an EDI environment in healthcare. The set can be used to transmit specific data in the form of a debit, credit or request for credit relating to pre-authorized product transfer actions. This guideline also contains codes to identify third-party pharmacy billing and eligible entities, and it allows for serialization data to be incorporated. These guidelines are part of HDA’s series of chargeback process-related guidelines, following 2019’s 845 Price Authorization Acknowledgement Status and 2020’s 849 for Response to Product Transfer Account Adjustment.